Richard T Di Giulio
- Office Location: A346b Lev Sci Res Ctr
- Office Phone: (919) 613-8024
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Email Address:
Research Area(s): environmental toxicology
environmental genomics
environmental health
estuarine ecosystems
marine biomedicine
water quality
Dr. Di Giulio serves as Director of Duke University's Integrated Toxicology Program and the Superfund Basic Research Center. Dr. Di Giulio's research is concerned with basic studies of mechanisms of contaminant metabolism, adaptation and toxicity, and with the development of mechanistically-based indices of exposure and toxicity that can be employed in biomonitoring. The long term goals of this research are to bridge the gap between mechanistic toxicological research and the development of useful tools for environmental assessment, and to elucidate linkages between human and ecosystem health. The bulk of Dr. Di Giulio's work employs a comparative approach with aquatic animals, particularly fishes, as models. Of particular concern are mechanisms of oxidative metabolism of aromatic hydrocarbons, mechanisms of free radical production and antioxidant defense, and mechanisms of chemical carcinogenesis, developmental perturbations and adaptations to contaminated environments by fishes.
Recent Publications (More Publications)
- Di Giulio, R.T. and M.C. Newman, Ecotoxicology, , (2008)
- Timme-Laragy, A.R., P.D. Noyes, D.R. Buhler, and R.T. Di Giulio, CYP1B1 knockdown does not alter synergistic developmental toxicity of polycyclic aromatic hydrocarbons in zebrafish (Danio rerio), Marine Environmental Research, vol. 66 no. 85-87 (2008)
- Di Giulio, R.T., and D.E. Hinton, The Toxicology of Fishes, , (2008)
- Rotchell, J.M., D.E. Hinton, M.R. Miller, R.T. Di Giulio, and G.K. Ostrander, Chemical carcinogenesis in fishes, , (2008), ppt. 531-598
- Matson, C.W., A.R. Timme-Laragy, and R.T. Di Giulio, Fluoranthene, but not benzo[a]pyrene, interacts with hypoxia resulting in pericardial effusion and lordosis in developing zebrafish, Chemosphere, vol. 74 (2008), ppt. 149-154
