Richard T. Di Giulio
Professor (primary appt: Nicholas School of the Environment) and Director, Superfund Basic Research Center; Director, Integrated Toxicology Program.
Dr. Di Giulio serves as Director of Duke University's Integrated Toxicology Program and the Superfund Basic Research Center. Dr. Di Giulio's research is concerned with basic studies of mechanisms of contaminant metabolism, adaptation and toxicity, and with the development of mechanistically-based indices of exposure and toxicity that can be employed in biomonitoring. The long term goals of this research are to bridge the gap between mechanistic toxicological research and the development of useful tools for environmental assessment, and to elucidate linkages between human and ecosystem health. The bulk of Dr. Di Giulio's work employs a comparative approach with aquatic animals, particularly fishes, as models. Of particular concern are mechanisms of oxidative metabolism of aromatic hydrocarbons, mechanisms of free radical production and antioxidant defense, and mechanisms of chemical carcinogenesis, developmental perturbations and adaptations to contaminated environments by fishes.
- Office Location: A346b Lev Sci Res Ctr
- Office Phone: (919) 613-8024
- Email Address:
|PhD||Virginia Polytechnic Institute and State University|
|MS||Louisiana State University|
|BA||University of Texas at Austin|
Awards, Honors, and Distinctions:
- US EPA Science and Tecnological Achievement Award, US EPA, July, 2010
- ENVIRON 501.01 - ENVIRONMENTAL TOXICOLOGY
Representative Publications: (More Publications)
- AJ Bone, BP Colman, AP Gondikas, KM Newton, KH Harrold, RM Cory, JM Unrine, SJ Klaine, CW Matson, RT Di Giulio, Biotic and abiotic interactions in aquatic microcosms determine fate and toxicity of Ag nanoparticles: part 2-toxicity and Ag speciation., Environmental science & technology, vol 46 no. 13 (2012), pp. 6925-33 [abs].
- LV Garner, RT Di Giulio, Glutathione transferase pi class 2 (GSTp2) protects against the cardiac deformities caused by exposure to PAHs but not PCB-126 in zebrafish embryos., Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, vol 155 no. 4 (2012), pp. 573-9 [abs].
- BW Clark, RT Di Giulio, Fundulus heteroclitus adapted to PAHs are cross-resistant to multiple insecticides., Ecotoxicology (London, England), vol 21 no. 2 (2012), pp. 465-74 [abs].
- Zhao, B., J.E.S. Bohonowych, A. Timme-Laragy, D. Jung, A.A. Affatato R.H. Rice, R.T. Di Giulio, and M.S. Denison, Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor, PLOS One (Accepted, 2012).
- Committee on Human and Environmental Exposure Science in the 21st Century, Exposure Science in the 21st Century: A Vision and a Strategy (2012).